Two-year-old Matheryn Naovaratpong. Image provided by the family.
In that first surgery, doctors extracted half the tumor and drilled through Einz’s skull to relieve the pressure on her brain. After it was over, they told her parents, both of whom are PhD-holding scientists, that she would probably never awaken. Even if she did, they said, the cancer was incurable—the hospital advised them to take Matheryn off life support.
“But in a week,” Dr. Sahatorn Naovaratpong told me in an email, “Einz woke up and regained her 2 years’ consciousness, she responded to stimulation, and surprised everyone. Einz represents the worth of Life.” Sahatorn is Matheryn’s father. (He spoke to me via email through his sister Dararat, who translated the messages.)
The event inspired the family to push on with treatment. “We decided to fight against this cancer,” Sahatorn told me. “We may not beat it, but her life can lead to a further step of mankind to overcome cancer in the future.”
Over the next year, the two-year-old would receive 12 brain surgeries, 20 chemotherapy treatments, and 20 radiation therapy sessions. Einz lost 80 percent of her left brain, essentially paralyzing the right side of her body. There were moments of great hope and pitched sorrow; Sahatorn described the period as an emotional roller coaster.
“[W]e noticed a power struggling for life in her beautiful round eyes,” he said. “Finally, Einz was able to stand up on her feet again and could see with both eyes, as if she had survived from brain cancer. Couldn't help wishing she could be back to her normal childhood even with only a single right brain.”
She regained her vision, the ability to stand, and, with therapy, began moving some parts of the right side of her body. She outlasted other patients in the treatment ward, according to Sahatorn. Many ependymoblastoma victims perish before they turn two.
The Naovaratpong family began doing social media outreach to raise awareness of childhood cancer, and started a genetic cancer research foundation. “Let Einz be the first to guide us,” was their motto, Sahatorn said.
But in November 2014, the cancer spread across Matheryn’s brain, and finally paralyzed her face and muscles.
“We realized it was the end,” Sahatorn said. “We had to prepare to say goodbye.” On January 8th, 2015, Matheryn was released from the hospital. She was fully conscious.
“Among family and relatives, we played and held her before we relieved her from the life support system, released her heavy load off her shoulder at 18:18,” Sahatorn told me. The “cancer cells and other cells from her body have been kept for further study.”
“Her body has been cryopreserved in Arizona awaiting coming technology,” he said.
This year, Matheryn
Alcor is one of the largest organizations that practices cryonics, the act of preserving humans and mammals in a freezing “biostasis” for later resuscitation. Alcor’s chief mission objectives are as follows: “Maintain the current patients in biostasis. Place current and future members into biostasis (when and if needed). Eventually restore to health and reintegrate into society all patients in Alcor's care.” For a fee, Alcor claims to be able to preserve the bodies that have deteriorated beyond modern medicine’s ability to help, until the day that science and biotech might improve enough to restore them.
Over the years, Alcor’s physicians and technicians have performed over 130 cryopreservations. Matheryn is their latest patient.
As a whole, the field of cryonics has been undergoing something of a renaissance. In the last decade, an open letter declaring cryonics “a legitimate science-based endeavor” has collected 63 signatures from doctors and researchers, the practice has become a core plank of the transhumanist movement, and its key players have crept steadily closer to the mainstream spotlight. Cryonics has earned high-profile supporters; baseball legend Ted Williams was famously frozen by Alcor.
In the process, the company has contended with accusations of impropriety—in an exposé book and an interview with ABC, an ex-Alcor employee claimed that the company used a chisel and a hammer to remove one patient’s head, and that it may have administered a lethal drug dose to a still-living member. Alcor denies the allegations, and filed a lawsuit against the employee.
The major cryonics organizations are still based solely in the US (the Cryonics Institute, for instance, is probably Alcor’s largest “competitor”). Besides Alcor’s UK chapter, the only other serious international operation is a fledgling Russian outfit, KrioRus. But due to renewed interest and the expanding reach of social media, word has spread far abroad.
“The family learned about Alcor on the internet,” Marji Klima, a spokesperson for Alcor told me. “They were both doctors. After they did 11 surgeries, when they realized that she wasn’t going to be able to pull through, they contacted us.”
Alcor agreed to accept Matheryn as a patient, and enrolled her as a member. The initial plan was to fly Einz to the United States while she was still alive, so Alcor's team could perform the procedure domestically. That procedure is complex and highly invasive; the BBC calls it “intense.”
Alcor's facility in Scottsdale. Image: Xavier Aaronson
It involves moving the patient onto an ice bed, coating her in freezing materials, artificially restarting the heart with a “heart-lung-resuscitator,” administering over a dozen different medications, draining the blood and replacing it with medical grade antifreeze, opening the chest cavity to attach the major blood vessels to a machine that flushes out all remaining blood, then slowly lowering the body’s temperature, at a rate of 1˚ Celsius every hour. (After two weeks, the body reaches deep cryofreeze at -196˚ C.) Alcor had selected
“It was hoped that this young 2-year-old girl was going to relocate to this hospital as her health declined so distance would be minimized,” Drake told me in an email. “Unfortunately, her breathing declined more quickly than her doctors anticipated and two days before she was to fly to the US, she was placed on a ventilator, essentially eliminating the possibility for airline travel.”
Alcor would have to go to her.
“We decided to have a physician go,” Klima said, “because of her age and her size, they wanted someone who was very skilled. When you’re looking at the vasculature of a small child like that, it’s a very different thing. And this was a small child with multiple brain tumors.”
So Alcor flew Drake and Dr. Jose Kanshepolsky, a retired neurosurgeon, to Thailand. They spent two days on “standby,” Alcor’s term for the phase of the cryopreservation process in which physicians remain stationed near the ailing member, waiting for her to pass and preparing for the procedure. Kanshepolsky examined the girl at the hospital before she was taken home, and discovered an alarming complication: since so much of her brain had been removed, her skull had filled with cerebrospinal fluid, which would make the procedure difficult.
Matheryn’s procedure was what Alcor calls a “neuro” in shorthand—where ultimately, just the brain is extracted and preserved, as opposed to the entire body
According to Drake, they decided “to undertake cryoprotective perfusion of Matheryn’s brain in Thailand.” The team decided to do so without separating her brain from the rest of the body. “This worked out to be an effective way to move through the repatriation process and back to the US,” Drake wrote in a post-procedure synopsis co-authored with Alcor CEO, Max More.
“On the second day, Matheryn was pronounced by a physician who was present at the bedside when clinical death occurred,” they wrote. “A surgery suite had been prepared in an adjoining room and access to the patient for stabilization and perfusion was immediate. Alcor’s field cryoprotection system was tested in the very remote field and proved effective.”
The surgical procedure went off without incident. “It went very smoothly,” Klima said. “It went better than some of the ones that happen right in our backyard.”
But since this was in fact very far from Alcor’s backyard, arrangements had to be made to transport Matheryn’s body to Arizona.
"Typically we’d move the head from the trunk of the body," Drake told me. "We didn’t know what their reaction would be from the family, the mortuary, from border officials; this has to go through a number of shipping venues, customs, the TSA and so on.
“After the US Embassy in Thailand approved the shipment, the container was topped off with dry ice and shipped by airline to LAX for customs approval,” according to the official account.
Matheryn’s procedure was what Alcor calls a “neuro” in shorthand—where ultimately, just the brain is extracted and preserved, as opposed to the entire body. Her brain is now stored in a “Bigfoot Dewar,” a stainless steel, vacuum-insulated container filled with liquid nitrogen and kept at -196˚C, along with dozens of other masses of grey matter. The core of Einz’s two-year-old being now rests in cryofreeze in Arizona, in wait of a cure, and a means to regrow her body.
“It took a tremendous amount of logistical planning, but yes, we are very pleased with the results,” Drake told me.
Matheryn's brain now resides in a Dewar like this. Image: Xavier Aaronson
The desire for eternal life—or even just another shot—is about as universal as it gets, so it's unsurprising that cryonics has begun to traverse international boundaries. “We have had a lot requests from overseas,” Klima told me, but Alcor doesn’t yet have the resources or the infrastructure to grant them all.
The expense is prohibitive, but not astronomical. A membership, which guarantees the signee the right to be put on “standby” (and earns him or her an Alcor Emergency ID tag), costs $770 a year, in addition to proof that financial arrangements for the final procedure have been made. Cryopreservation costs between $80,000 (for a “neuro”) and $200,000 (for the full body), depending on how much of her mortal coil a customer wishes to maintain. Alcor suggests prospective members purchase life insurance to cover the costs.
As an organization, Alcor has been hesitant to promote itself, Drake said. "I think the board is
How do you reanimate a deceased human body? Even the CEO of Alcor doesn’t claim to know
Those who've heard about Alcor online and have gone seeking life extension services in Europe or elsewhere have started clubs, societies, and turned to web forums. One group of advocates was so hopeful for a European cryonics organization it was tricked into thinking a publicity stunt featuring a group called the Siberian Mammoth, which promised to preserve British rappers in permafrost, was real.
Parents are bringing their kids on board, even when they’re not sick. “Our youngest member is three months old,” Klima said. “Families sign them up.” The process is legal, Drake says, if parents prove legal guardianship of the minors. "The parents can make the decision for the child while they're still a minor. The child can opt out if they choose."
“Alcor provides the opportunity for Einz to breathe again when the technology is provided and appropriate for her disease,” Matheryn's father said. Her family is grateful for Alcor, but they are not mindlessly idealistic. They are a family of doctors, and the lesson they took from their daughter’s battle with cancer is that there are still considerable frontiers left to be examined when it comes to medicine and human physiology. Matheryn's life was made possible by modern science in the first place, Sahatorn said; she was carried by a surrogate because her mother had lost her uterus birthing a son.
“Treating cancer needs changes,” Sahatorn said. “The conventional methods could not treat Ependymoblastoma and many types of cancer. We need more research about genetic cancers. Without research, there will be no change.” To that end, Matheryn’s parents will continue to promote the children’s cancer research initiative they began, which will be managed by the Rama Foundation. Part of the reason they turned to Alcor was to continue the advancement of such research.
"They didn't want their daughter's life to end in vain," Drake said. "They're hoping that by preserving the tissue cells of this particular cancer, they can come up with a better treatment plan, and maybe even eventually cure it. If you look at the global picture of what they're trying to accomplish, it's very altruistic." The Naovaratpongs are never going to stop fighting their daughter's disease, ever.
“We used conventional methods for more than 50 years now,” Sahatorn said. “It seemed to be hopeless until today.”
Of course Alcor is all about hope. It’s highly uncertain whether science will ever uncover a way to fundamentally repair the damaged bodies of the past. James Lovelock may have reanimated frozen rats, but that's a far cry from rejuvenating whole humans who have been locked in icy stasis for decades. It's a hope that is contingent on a great many future factors aligning.
How do you then reanimate a deceased human body? Even the CEO of Alcor doesn’t claim to know—he, along with thousands of the hopeful living, and hundreds of the frozen dead, have stocked their faith in the notion that science will find a way to thaw and revive the brain of a two-year-old girl.
“At least, we devoted her life and body for the progress and development of science," Nareerat, Matheryn's mother, told me in our lone communication. "This is also another treat for our family, we know that she's alive although we have been separated."